The expression of PTEN and telomerase in colorectal cancer and polyp

Abstract

Objective To investigate the expression of telomerase and tumor-suppressor gene PTEN, and their association with pathologicalcharacteristic and clinical significance. Method Immunohistochemical staining was used to evaluate the expression of telomerase and PTEN in 68 cases of colorectal polyps, 25 cases of normal tissues adjust to polyps, 15 cases of colorectal cancer tissue and its adjacent tissues in 9 cases. Result The expression of telomerase(80.00%)was significantly higher in colorectal cancer tissue than that in paracancerous tissues(22.22%), tissue of colorectal polyps(19.12%)and Polyps adjacent tissues(0%). The expression of PTEN was significantly decreased in colorectal cancer tissue(20.00%)than that in paracancerous tissues(77.78%), tissue of colorectal polyps(54.41%)and Polyps adjacent tissues(80.00%). In colorectal cancer and polyps tissues, the expression of telomerase and PTEN both had a negative correlation.(r=-0.516; r=-0.261). The expression of telomerase is closely related with polyp size(r=0.262). The expression of telomerase and PTEN is closely related to regional lymph node metastasis(r=0.560; r=-0.707). Conclusion The expression of PTEN was lack in colorectal cancer tissues, showed a missing tendency in the adenomatous polyp.the expression of telomerase and PTEN had a negative correlation in colorectal cancer and colorectal polyps.The change of two genes is possibly associated with malignant degree and development of colorectal tumors. Key words: Telomere; Enzymes; Colorectal neoplasms; Intestinal polyps; Immunohistochemistry; PTEN