Abstract
目的 探讨Parkin基因mRNA及其蛋白在肝细胞癌中的表达规律及其临床意义.方法 应用逆转录-聚合酶链反应(RT-PCR)和免疫组织化学(S-P)法检测58例肝细胞癌中Parkin基因mRNA及蛋白的表达情况,结合病人的临床病理资料分析Parkin基因在肝细胞癌中的意义.结果 肝癌组织中Parkin基因mRNA及蛋白的表达明显降低,阳性率分别为22.4%(13/58)和25.9%(15/58),明显低于癌旁肝组织的表达阳性率:94.8%(55/58)和89.7%(52/58),其差异有统计学意义(P＜0.05),且Parkin基因蛋白表达的缺失与病人的性别、肿瘤的大小、甲胎蛋白(AFP)、HBsAg、以及有无肝硬化无关(P＞0.05),而与肿瘤的分化程度、有无包膜及有无门静脉癌栓有关(P＜0.05).结论 Parkin基因在肝细胞癌的发生过程中可能起重要的作用,其表达水平可能成为肝细胞癌诊断及判断其生物学特性的重要分子生物学指标。
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