Abstract
BAG-1 is a multifunctional anti-apoptotic protein that binds to a variety of cellular proteins and affects their functions. It has been proven that overexpression of BAG-1 was observed in a number of human maligancies and correlated with their prognosis. The aim of this study is to determine BAG-1 mRNA expression in human lung cancer tissues and its clinical significance. The expression of BAG-1 was detected by real-time PCR in formalin-fixed, paraffin-embedded human lung cancer tissues of 156 cases. (1) The median survival time (MST, 33.5 months) in BAG-1 low-expression group was significantly higher than that (20.5 months) in BAG-1 highexpression group (P <0.005); (2) The 3-year and 5-year survival rates (44.74%; 26.32%) in BAG-1 low-expression group were dramatically higher than that in BAG-1 high-expression group (32.5%; 21.25%)(P <0.05), respectively. The survival curves in BAG-1 low-expression group was also significantly better than that in BAG-1 high-expression group (P =0.045); (3) The further analysis indicated that the survical curves in BAG-1 low-expression group were much better than that in BAG-1 high-expression group in the lung cancer patient with TNM stage I, or with squamous cell cacrinoma, or without any metastasis, respectively (P <0.05). BAG-1 may be a biomarker for the prognosis of lung cancer patients, especially for the lung cancer patients with stage I or squamous cell carcinoma.
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