Abstract
Objective To investigate the relationship between expression of forkhead box C1 (FOXC1) and clinicopathological and survival parameters in colon cancer, and predict the related genes and signaling pathways. Methods FOXC1 expression and clinicopathological information were downloaded from genome microarray of gene expression omnibus (GEO) database. The correlation between FOXC1 expression and clinicopathological factors and prognosis was analyzed. The R2 platform was used to search the genes associated with a significant expression with FOXC1. The gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses were performed. Results There was a significant correlation between the expression of FOXC1 and tumor differentiation (χ2=7.919, P=0.019). High expression of FOXC1 indicated poor prognosis (P=0.045). In total, 608 genes were identified which were associated with a significant expression with FOXC1 (387 up-regulated genes and 221 down-regulated genes). GO analysis results showed that these genes were significantly enriched in biological processes, including angiogenesis, cell proliferation, cell apoptosis, cell adhesion, transcription factor binding, and epithelial to mesenchymal transition etc. The pathway analysis showed that these genes were mainly involved in Wnt signaling pathway. Conclusions The expression of FOXC1 indicates poor prognosis of colon cancer and can be used as a potential prognostic marker. The related genes set of FOXC1 were enriched in multiple biological processes and signaling pathways. This study provides guidance for the further study in colon cancer. Key words: Colon cancer; Gene expression; Forkhead box C1 (FOXC1); Gene microarray
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