Abstract
Trehalases (treh) have been found in different organisms, such as bacteria, fungi, yeast, nematodes, insects, vertebrates, and plants. Their biochemical properties are extremely variable and not yet fully understood. Gene expression patterns have shown differences among insect species suggesting a potential functional diversification of trehalase enzymes during their evolution. A second gene family encoding for enzymes with hypothetical trehalase activity has been repeatedly annotated in insect genome as acid trehalases/acid trehalase-like (ath), but its functional role is still not clear. The currently available large amount of genomic data from many insect species may enable a better understanding of the evolutionary history, phylogenetic relationships and possible roles of trehalase encoding genes in this taxon. The aim of the present study is to infer the evolutionary history of trehalases and acid trehalase genes in insects and analyze the trehalase functional divergence during their evolution, combining phylogenetic and genomic synteny/colinearity analyses.
Highlights
Trehalases, commonly found in different organisms (Jorge et al, 1997), catalyze the hydrolysis of trehalose into two glucose molecules (Becker et al, 1996)
Trehalases have been shown to exist as a soluble form and as a membrane bound form and they play a pivotal role in energy metabolism, chitin biosynthesis, flight and in many other physiological processes, including development and reproduction (Candy, 1974; Shukla et al, 2014)
Combining the different role to the variable biochemical properties of trehalases it has been suggested that a functional diversification of trehalase enzymes occurred during insect evolution
Summary
Trehalases, commonly found in different organisms (such as bacteria, fungi, yeast, nematodes, insects, vertebrates, and plants) (Jorge et al, 1997), catalyze the hydrolysis of trehalose into two glucose molecules (Becker et al, 1996). Combining the different role to the variable biochemical properties of trehalases it has been suggested that a functional diversification of trehalase enzymes occurred during insect evolution Acid trehalases are mainly described in bacteria and fungi (Destruelle et al, 1995; D’Enfert and Fontaine, 1997; Inagaki et al, 2001; Murata et al, 2001) and the origin of such genes in insect genomes is still unexplained
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