Abstract
Developing nanocrystalline drug delivery technologies is a noteworthy advancement in pharmaceutical science. The nanocrystalline formulations aim to improve therapeutic efficacy, pharmaceutical solubility, and bioavailability. We develop many methods for their fabrication, with top-down, bottom-up, and combination procedures, beginning with reasoning behind nanocrystalline approaches. In this type of review, we focused on the progress of nanocrystalline drug delivery systems in various years by applying different techniques which started in 1990 and what dosage forms are still made by this technology. It is found that various other techniques are also there manufacturing of drug Nanocrystals through years of investigation made by specialists. The researchers found methods such as Top-down, bottom-up, combination, solvent displacement technology, fluidised bed technology, freeze drying, spray drying, electrodynamic technique, and melt emulsification. Every process has advantages and disadvantages, therefore selecting the proper technology is critical to produce drug nanocrystals successfully. Keywords: Nanocrysyals, CT, Bottom-up, Top-Down, HPH, Nanocarriers
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