Abstract
K. pneumoniae and Past. pseudotuberculosis in the presence of high blood-lipid levels produced a pneumonitis in rabbits characterized by deposition of large quantities of cholesterol and fat in the inflammatory areas. The pathologic lesions closely resembled “cholesterol,” “endogenous lipid,” or “foam cell” pneumonia previously described in human beings and were similar to several other types of xanthomatous lesions. In the presence of normal blood-lipid levels, fat and cholesterol also appeared in small amounts in chronically inflamed areas. Similar phenomena occurred in ischemic muscle, suggesting that the process was dependent upon local physicochemical conditions. The suggestion is made that local acidosis developing in an injured or infected tissue has an adverse effect upon the colloidal lipids. The effect of lowered pH is largely on the charge exhibited by colloidal lipids and proteins. The pathologic significance of the reaction between basic proteins, phospholipids, and negatively charged (anionic) lipids is discussed.
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