The essential oil from Ferulago angulata (Schltdl.) Boiss. fruits exerting potent analgesic and anti-inflammatory effects.

Abstract

Ferulago angulata is an aromatic herb that its fruits are utilized widely in Persian traditional medicine as a painkiller and reliving inflammation-based disorders. Considering the higher content of essential oil in the fruits, the oil's anti-inflammatory and analgesic activities were investigated in an animal model in vivo. The analgesic effects of F. angulate fruits essential oil was evaluated via testing the writhing triggered by acetic acid examination and hot plate technique. Moreover, the acute anti-inflammatory effects were studied through the paw edema triggered in mice. Using all examined doses (25, 50, and 100 mg/kg) of the oil revealed an analgesic impact considering the increment in the reaction time needed for the hot plate approach. Furthermore, 50 and 100 mg/kg doses of the oil caused a reduction in the frequency of writhes in the mice. It was observed that all examined doses of the oil (25, 50, and 100 mg/kg) caused inflammatory reduction. The findings indicated that the oil may possess significant activities against acute inflammation. It had both peripheral and central pain-killing impacts. cis-β-ocimene (58.0%) followed by α-pinene (10.0%) as the main constituents of the oil can be considered as the responsible compounds to manage the inflammation and pain.