Abstract
The presence of insulin during the irradiation of plateau phase baby hamster kidney, Chinese hamster ovary, Ehrlich tumor, human oral carcinoma, human laryngealcarcinoma, and V-79 cells improved radiation response. Insulin was also found to enhance the radiation response of multiceli V-79 spheroids. The radiosensitizing effect of insulin is both time and concentration dependent. Additional studies indicate that glucagon-free insulin and the insulin mimicking tripeptide, glyeyl-L-histidyl-L-lysine-acetate, also sensitize plateau phase cultures of V-79 cells to radiation.
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