Abstract
The effects of steroidal and non-steroidal anti-inflammatory agents on extracellular phospholipase A 2 (PLA 2) activity were investigated. Enzyme release was inhibited by 5 × 10 −8M dexamethasone but not by indomethacin, whereas the soluble extracellular enzyme was inactivated by mepacrine but not by dexamethasone or indomethacin. PLA 2, released into the interstitium by activated macrophages is both pro-inflammatory and vasoactive. The anti-inflammatory efficacy of steroidal and non-steroidal drugs may partially reside in their ability to inhibit the release of PLA 2, or inactive preformed extracellular PLA 2 in chronically inflamed sites.
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