Abstract

Following ventromedial tegmental lesions in the brain stem of monkeys, tyrosine hydroxylase activity is significantly lower on the lesion side of the caudate nucleus and putamen. The in vivo formation of dopamine-C 14 from tyrosine-C 14 is impaired on the lesion side in these two regions of the CNS. The present findings support the idea that ventromedial tegmental lesions produce a degeneration of dopamine neurons in the ipsilateral caudate nucleus and putamen.

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