Abstract
Silver nanowires (AgNWs) were synthesized and fabricated then their effects on the structure and esterase-like activity of Human Serum Albumin (HSA) were evaluated in vitro. Afterward, their impacts on the growth of human endometrial stem cells (hEnSCs) were studied. The results showed that AgNWs could form a complex with HSA and did not affect the secondary structure of HSA only at lower concentrations. The binding constant for the AgNWs-HSA complex was found to be 1.4 × 104 M−1. The distance between HSA and AgNWs was acquired according to the Förster theory. The value of ΔG ° displayed that AgNWs interact with HSA and the hydrophobic force plays a major role in this interaction. HSA lost its esterase-like activity at a higher concentration of AgNWs. Cell viability assays indicated that AgNWs were toxic toward hEnSCs at higher concentrations. This study demonstrated that AgNWs can be utilized in nanotechnology-based bio-applications only at lower concentrations.
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