Abstract
Fifty(50) blood samples of human red blood cell genotype HbAA were assayed in-vitro to determine the effect of increasing combined concentrations of pyrime- thamine and sulphadoxine (ratio 20:1w/w) solution on plasma levels of hemoglobin (Fe 2+)/methaemoglobin (Fe 3+) ratio. The concentrations used were 0.2, 0.4, 0.6, and 0.8%. The mean percentage plasma hemoglobin level of the control sample was 97.86 ± 0.74%, while the test samples at 0.2, 0.4, 0.6 and 0.8% concentrations showed hemoglobin levels of 96.52 ± 0.75, 96.72 ± 0.64, 97.42 ± 0.61 and 96.07 ± 1.49% respectively. The mean percentage methaemoglobin level of the control sample was 2.14 ± 0.74%, while the test samples at 0.2, 0.4, 0.6 and 0.8% concentration gave plasma methaemoglobin levels of 3.48 ± 0.75, 3.28 ± 0.64, 2.55 ± 0.61 and 3.93 ± 1.49% respectively. These result showed a concentration dependent variability with the percentage of pyrimethamine/sulphadoxine mixture that was added to the test samples. Statistical analysis showed a significant difference between the mean values of the control and test samples (p IJONAS Vol. 3 (1) 2007: pp. 116-121
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: International Journal of Natural and Applied Sciences
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
