Abstract
Exposure to polychlorinated biphenyls (PCBs) is implicated in adverse neurotoxic outcomes. However, the impact of PCBs on the adolescent nervous system has received inadequate attention. We conducted a comprehensive review to identify studies of neurotoxic outcomes following PCB exposure during the adolescent period in rodents. Only four papers were found to meet all inclusion criteria. PCB exposure in adolescent rats caused disruptions in the main functions of the prefrontal cortex, resulting in cognitive deficits. This comprehensive review demonstrates that more research is needed to characterize how PCB exposure adversely affects the adolescent nervous system.
Highlights
Polychlorinated biphenyls (PCBs) are a class of 209 industrial chemicals that contain a biphenyl moiety with 1−10 chlorine substituents
In the United States, recent studies show that PCBs are present in the indoor air of older schools due to their release from building materials.[1]
This age range in rodents is relevant to children in schools, from kindergarten, age 5, to high school, age 18−19.4 Using this broader definition of adolescence, we performed a comprehensive review and evaluated the scientific rigor of relevant papers using the ToxRtool, an open-access, user-friendly tool to evaluate toxicology studies (Figure 1).[5−8]
Summary
Polychlorinated biphenyls (PCBs) are a class of 209 industrial chemicals that contain a biphenyl moiety with 1−10 chlorine substituents. Rodent adolescence is typically postnatal days (PND) 28−55.4 early PCB exposure can alter adolescent timelines, with male rats taking longer to reach full adult maturity and female rats developing earlier with precocious menarche.[1] we defined adolescence in rodents as PND21−PND60, expanding the window of adolescence to encapsulate the full range of potential brain growth during this period This age range in rodents is relevant to children in schools, from kindergarten, age 5, to high school, age 18−19.4 Using this broader definition of adolescence, we performed a comprehensive review and evaluated the scientific rigor of relevant papers using the ToxRtool, an open-access, user-friendly tool to evaluate toxicology studies (Figure 1).[5−8]. Perspective described in the Supporting Information, scientific rigor was evaluated with the open access ToxRtool.[5−8] The key findings from these studies, including their ToxRtool rating, are discussed below (Table 1)
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