Abstract
Urinary 6β-hydroxycortisol is a useful, non-invasive index of microsomal mixed-function oxidase activity in man (review: [1]). Administration of phenobarbitone (40 mg/kg/day) for 4 days to male guinea-pigs, produced significant increases in hepatic microsomal cytochrome P-450 content and cytochrome P-450 reductase activity but did not increase 6β-hydroxycortisol excretion. The lack of relationship between urinary 6β-OHC excretion and microsomal mixed-function oxidase activity in the guineapig may be accounted for by the finding that 6β-hydroxycortisol itself undergoes extensive and variable metabolism in the guinea-pig
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