Abstract
Intestinal crypt survival was studied in mice irradiated in air, 100% normobaric oxygen, 100% hyperbaric oxygen (30 psi), and 6% normobaric oxygen. Exposures from 900-2000 R at the rate of 47 R/min. Intestinal crypt survival was determined by the method of Hagemann, Sigdestad, and Lesher (4). The results demonstrated no difference in crypt survival for mice irradiated in air, normobaric oxygen, or hyperbaric oxygen. The crypt survival of mice was shown to have a D0 from 377 to 380 R and a n from 7.9 to 9.7 for mice irradiated in air, 100% oxygen, or 100% oxygen at 30 psi, while mice irradiated in 6% oxygen had a $D_{0}=529$ R with a n=8.1. The DMF (ratio of D0 in 6% oxygen to D0 in oxygen) was found to equal 1.4. The lack of difference in air and oxygen suggests the highly vascularized (oxygenated) gut is maximally sensitive. Animal lethality ( ${\rm LD}_{50(5)}$ ) is compared with crypt survival.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
