Abstract
Background:Previous evidence has demonstrated that serum leptin is correlated with appetite in combination with, but not without, modest exercise.Aim:The present experiments investigated the effects of exogenous adrenaline and α/β adrenoceptor blockade in combination with moderate exercise on serum leptin concentrations, appetite/satiety sensations and subsequent food intake in obese women.Methods:A total of 10 obese women ((mean ± SEM), age: 50 (1.9) years, body mass index 36 (4.1) kg/m2, waist 104.8 (4.1) cm) participated in two separate, double-blind randomised experimental trials. Experiment 1: moderate exercise after α/β adrenergic blocker (labetalol, 100 mg orally) versus moderate exercise plus placebo; experiment 2: adrenaline infusion for 20 minutes versus saline infusion. Appetite/satiety and biochemistry were measured at baseline, pre- and immediately post-intervention, then 1 hour post-intervention (i.e., before dinner). Food intake was assessed via ad libitum buffet-style dinner.Results:No differences were found in appetite/satiety, subsequent food intake or serum leptin in any of the studies (experiment 1 or experiment 2). In experiment 1, blood glucose was higher (p < 0.01) and plasma free fatty acids lower (p = 0.04) versus placebo. In experiment 2, plasma free fatty acids (p < 0.05) increased after adrenaline versus saline infusion.Conclusions:Neither inhibition of exercise-induced adrenergic activity by combined α/β adrenergic blockade nor moderate increases in adrenergic activity induced by intravenous adrenaline infusion affected acute appetite regulation.
Highlights
Obesity is the most prevalent single disease in the world (International Classification of Diseases 10 code E.66), with more than 2.1 billion overweight adults (Ng et al, 2013)
We examined the effects of exogenous adrenaline and a-/b-adrenoceptor blockade in combination with moderate exercise on serum leptin concentration, appetite/satiety sensations and food intake in obese women
Plasma NA concentration increased to 2.3 nmolÁlÀ1 at the end of the adrenaline infusion, typical of the suppressed levels found during exercise in obesity; substantial variation was reported in NA concentration during intense or exhaustive exercise in obese, young individuals (Zouhal et al, 2013)
Summary
Obesity is the most prevalent single disease in the world (International Classification of Diseases 10 code E.66), with more than 2.1 billion overweight adults (Ng et al, 2013). In experimental rodent models and in cases of congenital obesity, leptin is a key regulator promoting satiety. Previous evidence has demonstrated that serum leptin is correlated with appetite in combination with, but not without, modest exercise. Aim: The present experiments investigated the effects of exogenous adrenaline and a/b adrenoceptor blockade in combination with moderate exercise on serum leptin concentrations, appetite/satiety sensations and subsequent food intake in obese women. Results: No differences were found in appetite/satiety, subsequent food intake or serum leptin in any of the studies (experiment 1 or experiment 2). In experiment 2, plasma free fatty acids (p < 0.05) increased after adrenaline versus saline infusion. Conclusions: Neither inhibition of exercise-induced adrenergic activity by combined a/b adrenergic blockade nor moderate increases in adrenergic activity induced by intravenous adrenaline infusion affected acute appetite regulation
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