Abstract
Background: Serotonin and norepinephrine are known as agents of the nonopiate endogenous descending pain control system. Recently, selective serotonin norepinephrine receptor inhibitors (SNRIs) have been developed as antidepressants. We studied the effects of milnacipran, a SNRI in a spinal nerve ligation (SNL) model and formalin test. Methods: Male Sprague-Dawley rats weighing 200-250 gm were used for this study. In the SNL model, under an anesthetic state, the 5th lumbar spinal nerve was ligated and a PE-10 catheter was inserted into the subarachnoid space. Milnacipran was injected intraperitoneally or intrathecally and the threshold of tactile allodynia was measured. In the formalin test, milnacipran was administered intraperitoneally or intrathecally. 30 minutes after intraperitoneal injection or 60 minutes after intrathecal injection the formalin test was performed and flinching was counted for 60 minutes. Results: In the spinal nerve ligation model, pain response decreased significantly (P
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