Abstract
Objective: We have previously demonstrated that isolated hearts transplanted in miniature swine across an MHC class I barrier and treated with 12 days of CyA or transplanted across a full MHC barrier and treated with FK506 rejected their allografts within 55 days. In contrast, hearts co-transplanted with kidneys and transplanted across the same MHC barriers with the identical treatment survived indefinitely. The kidney allografts were explanted from the class I mismatch recipients more than 100 days after the transplant and replaced with recipient-matched kidneys. Around one hundred days later, challenge skin grafts, including those expressing donor class I, 3rd party class II antigens, were placed which led to acute rejection of the previously stable heart grafts within 41 days. Here, we asked whether the same result would be obtained in recipients of fully mismatched heart and kidney grafts.
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