Abstract
Publisher Summary This chapter discusses some of the effects of innervations on the localization and the properties of the receptor. It describes the properties of receptors in the normally innervated and discusses the effects of innervation on the properties of receptors. The inverse relation between the muscle activity and the number of acetylcholine (ACh) receptors is found both in vivo and in vitro. One possible mechanism by which activity might control receptor content is by way of the intracellular calcium concentration. The average intracellular calcium level increases with activity and this could inhibit the synthesis of receptors. The denervation of the electric organ of Electrophorus electricus is without effect on the extrajunctional receptor density. The chapter discusses the effects of the spontaneous fibrillation found both in vitro and in vivo following denervation as activity plays a role in the level of ACh receptor content.
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