Abstract
The effects have been examined of hydrazines, primarily unsymmetrical dimethylhydrazine and symmetrical dimethylhydrazine, upon pyridoxal phosphate in rat brain. No significant change was found. Injected pyridoxal phosphate was as effective as pyridoxine in raising brain pyridoxal phosphate levels, although only pyridoxine is therapeutic for dimethylhydrazine poisoning. It is concluded that the toxic action of these hydrazines is not due to a direct effect upon brain pyridoxal phosphate.
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