Abstract
The current evidence-base regarding the effect of hesperidin (a flavanone found in citrus fruits) on body composition is equivocal. We conducted a meta-analysis on the effect of orange juice and/or hesperidin supplementation on anthropometric measures in randomized controlled trials (RCTs). A systematic search of PubMed and Scopus was performed up to February 2020. The overall estimates and their 95% confidence intervals (CIs) were calculated using a random-effects model. Eleven eligible RCTs, with 512 individuals, were included in this study. The meta-analysis showed that orange juice and/or hesperidin had no significant effect on body weight [weighted mean difference (WMD)=-0.31kg; 95% CI,-1.44 to 0.82, P=0.592], body mass index [WMD=0.11kg/m2; 95% CI,-0.33 to 0.56, P=0.617], fat mass [WMD=0.14kg; 95% CI,-0.95 to 1.22, P=0.807], percentage body fat [WMD=-0.70%; 95% CI,-2.58 to 1.18, P=0.463] and waist circumference [WMD=0.07cm; 95% CI,-1.16 to 1.30, P=0.588]. The present study revealed that there is no significant beneficial effect of orange juice and/or hesperidin supplementation on anthropometric measures. The authors advocate that more high-quality clinical trials are needed to better discern the potential efficacy of orange juice and/or hesperidin.
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