Abstract
The effect of fluoride on bone metabolism was studied in rats. Since the urinary hydroxyproline (OHPro) is a good indicator for the level of bone resorption, OHPro in urine was mainly studied in rats exposed to chronic doses and/or acute doses of fluoride. As supplementary indicator, additional analyses were also done: calucium, phosphate and fluoride for urine; alkaline phosphatase activity, calcium and fluoride for serum; and analyses of those mineral contents and/or soft X-ray analysis for femurs.In the experiment with chronic doses of fluoride, lowered urinary levels of free and total OHPro were seen in the higher dose groups (100 and 200 ppm F). This finding indicates that bone resorption and collagen synthesis are depressed. In the medium dose groups (10 and 50 ppm F), however, high urinary levels of free and total OHPro were seen only the 15th experimental day, indicating a temporal acceleration of bone resorption. Further, an inter esting finding was seen in a lower dose group (1 ppm F): that is, a rising tendency in the urinary level of free OHPro was seen in this group. It may be suggested that the bone metabolism can be activated by optimum fluoride.On the other hand, abrupt and temporal bone resorption at the site of high metabolic activity may occur.No significant changes in serum alkaline phosphatase activity, serum calcium, urinary phosphate and urinary calcium were observed.
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