Abstract
Fenclozic acid, a prostaglandin synthesis inhibitor, was administered to male rats by stomach intubation. A second group of rats received the vehicle (1% methylcellulose) alone. The dose schedule used was 75 mg/kg on day 1, 50 mg/kg on day 2 and 25 mg/kg on days 3, 4 and 5. The dose was progressively reduced to eliminate the toxic effects seen in the initial stages of the treatment. All the animals had normal fertility and libido before treatment and during administration of the vehicle. However, sterility or sub-fertility was seen in 4 of the 6 animals treated with fenclozic acid. Sperm were always present in the vaginal smears. It was concluded that the reduction in fertility was probably caused by an effect of the drug on maturation or metabolism of the sperm.
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