Abstract
To examine the effect of gossypol on human sperm in vitro and the mechanism for the effect. Fresh sperm ejaculates obtained from normal donors to the University of Kentucky Andrology Donor Program were exposed to gossypol. Motility was studied manually and using computer-assisted sperm analysis. In subsequent experiments, the effects of forskolin, theophylline, and cyclic adenosine monophosphate (cAMP) on sperm motion were measured. University of Kentucky Department of Obstetrics and Gynecology Andrology Laboratory. Manual and computer-assisted measurements of sperm motility and motion characteristics. Gossypol inhibited sperm motility, which could be reversed partially by increasing cAMP. Gossypol exposure in vitro adversely affects sperm motility in a dose- and time-dependent manner by a cAMP-dependent mechanism.
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