Abstract
1. 1. The effects of CO 2 and HCO 3 - upon the unidirectional Cl-fluxes across isolated frog gastric mucosa were examined under normal conditions and during SCN- inhibition. 2. 2. When the nutrient solution was aerted with pure O 2 and the partial pressure of CO 2 on the secretory side ( P CO 2 s ) was raised, the backward Cl-flux from the secretory to nutrient side ( J sn Cl- ) decreased, whilst the forward Cl- flux from nutrient to the secretory side ( J ns Cl- ) increased. The extent of the inhibition of J sn Cl- by SCN-increased with the increase of P CO 2 s ) in a similar manner to the inhibition of ( J ns Cl- ). 3. 3. Nutrient CO 2 increased both the H + secretion rate ( Q H +) and J ns Cl- and SCN-inhibition more effectively than did secretory CO 2. Nutrient HCO 3-reduced this effect, whereas secretory HCO 3-affected the system only slightly. 4. 4. In order to explain the results consistently, a model for the SCN-inhibition of gastric mucosal anion exchange was constructed, in which SCN- inhibition was assumed as a dead-end one. 5. 5. The secretion process is interpreted as follow: H + is produced by the electron transfer system on the secretory side and the resultant concentration of OH- on the opposite side, facilitated by the action of CO 2, promotes the circulation of the anion-exchange carrier.
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