Abstract
Butylated hydroxytoluene pretreatment in the rat enhanced the total in vitro metabolism of aflatoxin B 1 by the hepatic postmitochondrial fraction (S-9) and increased the formation of aflation M 1, aflatoxin Q 1 and a metabolite tentatively identified as the aflatoxin-glutathione conjugate, the latter being the major metabolite produced. Addition of diethyl maleate, a glutathione deplethione depletor, to the incubation mix reduced formation of the conjugate. No significant difference between treated and control animals was observed in the S-9-mediated binding of aflatoxin B 1 to calf thymus DNA. However, the mutagenicity of aflatoxin B 1 in Salmonella typhimurium TA98 was significantly lower in the presence of S-9 from BHT-treated rats than with S-9 from controls.
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