Abstract
In the present study, we investigated whether blue light emission diode (LED) light exposure affects the maternal behavior of mice. The brain function of the offspring mice, including short-term memory, locomotor activity, anxiety-like behavior, and depression-like behavior, was evaluated. Pregnant mice at day 11 were housed in the apparatus for exposure to blue LED light during the daytime. Nesting behavior and the survival of pups were observed until weaning. After weaning, the offspring mice were bred in normal light conditions until 12 weeks old, and then the Y-maze test, open field test, and tail suspension test were performed. Retinal functions were evaluated by electroretinogram and histological analysis. Blue LED light exposure during the daytime induced retinal damage, but did not affect behavior related to maternal care in maternal mice. In the offspring mice, blue LED light exposure during the daytime did not affect the retina or brain functions. These findings suggest that blue LED light during the daytime might not be a risk factor for disruption of the mother-infant relationship or offspring brain development in mice.
Highlights
We investigated whether blue light emission diode (LED) light exposure affects the maternal behavior of mice
Blue LED light exposure during the daytime did not affect the retina or brain functions. These findings suggest that blue LED light during the daytime might not be a risk factor for disruption of the mother-infant relationship or offspring brain development in mice
We investigated whether blue LED light exposure affects the maternal behavior of mice
Summary
Video displays emit a large amount of blue light (400 - 500 nm), and blue light has been reported to be harmful to the retina [1] [2]. We reported the harmful effects of blue LED light to the retina in vitro and in vivo [2] [3]. Blue LED light has been reported to regulate the circadian rhythm [4] [5], and glucose metabolism [6]. An unknown physiological effect of blue LED light for higher brain function may be still present and needs to be clarified. It is critical to elucidate the effects of LED light on breeding behavior and physiology in housed animals. There are few studies to date evaluating the effects of LED light
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
