The effects of bilateral and unilateral frontal lesions on visual cortical hypersynchronous bursting and behavioral activity

Abstract

Photically evoked after-discharge (PhAD) bursting was examined in albino rats following either bilateral or unilateral dorsal frontal lesions. The initial effect of either type of frontal lesion was to significantly suppress PhAD occurrence. However, after repeated exposure to the PhAD recording environment no difference could be seen between the lesioned and control animals. In addition, no difference in PhAD could be detected between the two visual cortices in any of the groups. Spontaneous alternation and open-field activity were also tested. Both frontally lesioned groups of animals were significantly more active than control animals in the initial stages of testing. These findings indicate that the frontal cortex can inhibit brain stem mechanisms which are responsible for behavioral arousal and the modulation of hypersynchronous bursting in the cortex. However, because no difference was seen between the two visual cortices in any of the groups, it is suggested that this mechanism is not a strictly unilateral mechanism.