Abstract
We investigated the effects of a new selective beta 1-adrenoceptor partial agonist, ICI 118.587, on left ventricular function in 14 patients with coronary heart disease and a history of stable angina pectoris. The drug (0.2 mg/kg) increased peak left ventricular dp dt from 1518 to 1993 mm Hg/sec ( P < 0.001) and left ventricular V max from 1.63 to 2.08 circ/sec ( P < 0.001), while left ventricular end-diastolic pressure decreased ( P < 0.05). Measured by echocardiography, the fractional shortening of the left ventricular minor axis diameter and the mean velocity of the left ventricular circumferential fiber shortening increased ( P < 0.001) and the cardiac index increased by 36%, reflecting increased contractility mainly in the normal left ventricular wall areas. In coronary heart disease, ICI 118.587 increased left ventricular muscle contractility and output without untoward side effects in the majority of the patients.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
