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Abstract
The effects on guinea-pig tracheal muscle of a prostaglandin synthesis inhibitor, indomethacin, antagonist, SC-19220, and precursor, arachidonic acid have been studied in order to investigate the possible role of prostaglandins in the maintenance of respiratory smooth muscle tone. Indomethacin reduced the resting tone of the muscle, and increasing concentrations reduced the response to arachidonic acid without affecting the response to acetylcholine. Prostaglandins E 2 and F 2α caused contractions of indomethacin-relaxed muscle, and tachyphylaxis was induced by repeated exposure of the muscle to these agonists, but not to arachidonic acid. The prostaglandin antagonist, SC-19920 relaxed the muscle, and abolished its response to a standard dose of prostaglandin E 2. Increasing concentrations of SC-19220 reduced the responses to both arachidonic acid and large doses of prostaglandins E 2. The responses of tracheal muscle to arachidonic acid are concluded to be partly due to prostaglandin synthesis, supporting the hypothesis that this process maintains tracheal muscle tone.
Published Version
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