The Effects of Aging on Acoustic Parameters of Voice

BackgroundIncreased evidence has reported the association of genetic polymorphisms of Apolipoprotein E (APOE) with serum lipids. However, few studies have explored the combined effects of APOE, gender, and age.MethodsA total of 1,419 middle-aged and elderly subjects were randomly selected and studied. The APOE genotypes and the serum lipids were detected. The effects of APOE, gender, and age on serum lipids were preliminarily observed in general. The subjects were then divided into the middle-aged group (40–64 years old) and the elderly group (≥ 65 years old), for both males and females, to explore the combined effects of the APOE, gender, and age on serum lipids. Finally, a multivariate logistic regression model was used to evaluate the associations between the APOE allele carriers and the at-risk levels of dyslipidemia.ResultsThe serum TC, LDL-C, and ApoB in the ε2 carriers were lower than the ε3 carriers (all P < 0.05), and there was no significant difference in the ε4 carriers compared to the ε3 carriers in general (all P > 0.05). The serum LDL-C and ApoB of the ε2 carriers were lower than the noncarriers in the middle-aged and elderly males (all P < 0.05). The serum TC in the ε2 carriers was lower than the noncarriers only in middle-aged males (P < 0.05). As to the levels of serum HDL-C and ApoA1, the ε2 carriers were higher than the noncarriers in middle-aged females (all P < 0.05), and the ε4 carriers were lower than noncarriers in middle-aged males (P < 0.05). Especially, the serum TG in the ε4 carriers was significantly higher than the noncarriers in elderly females. The logistic regression analysis indicated that the ε2 carriers were less likely to have at-risk levels of high LDL-C in middle-aged and elderly males (all P < 0.05) versus low HDL-C in middle-aged females (P < 0.05). In contrast, the ε4 carriers were more likely to have at-risk levels of high TG in elderly females (P < 0.05).ConclusionsThe effects of the genetic polymorphisms of APOE on the serum lipids were both gender- and age-dependent in the middle-aged and elderly Chinese Fujian Han population.

Impact of age and sex on the relationship between carotid intima-media thickness and frailty level in the Canadian Longitudinal Study of Aging

The present investigation was undertaken to assess the macronutrient intake of the elderly (60- 80 years) from Central India. Four hundred elderly, which included 200 males and 200 females were selected from Nagpur city, Maharashtra, India, through stratified random sampling. All subjects were personally interviewed . T heir socio - demographic characteristics and general dietary practices were studied by specially formulated questionnaire s whereas quantitative daily food intake was assessed by 24 - hour recall method s. The data were analyzed according to age (60 – 70 Y; 70 – 80 Y) and sex using frequency distribution, percentages, mean and standard deviation. Pearson’s Correlation coefficient was used to determine the influence of the underlying determinants on macronutrient intake . Higher proportions of elderly males (31.5 %) were in the age group of 65- 70 years whereas 44% elderly females were from the age group of 60 -65 years. The majority of elderly males (91.5%) a nd females (73.5%) were married . Pension was the main source of income for the majority of elderly males (70.5%) and females (76.6%). 74% elderly females and 73% males were found to be consuming 4- 5 meals in a day. 92% and 91% of elderly females and males were consuming meals regularly , respectively. The percent adequacy for pulses, other vegetables, milk and milk products and fat in elderly males was higher than Recommended Dietary Intake whereas in elderly females the percent adequacy for other vegetables and fat was higher than Recommended Dietary Intake suggested for Indian adults . The mean intake of pulse s (z = 2.07 p&lt;0.05), other vegetable s (z = 2.03 p&lt;0.05), fruit s (z = 2.04 p&lt;0.05) and fat (z = 2.53 p&lt;0.05) was found to be significantly higher in elderly males of 60- 70 years than 70- 80 years. However, the dietary intake amongst the elderly females of 60- 70 years and 70- 80 years did not show any significant difference. Except fat intake in elderly females, consumption of all macronutrients was found to be less than Recommended Dietary Allowance suggested for adult Indians in both elderly males and females. The macronutrient intake in the elderly showed a significant negative correlation with age and positive correlation with number of meals consumed. Majority health problems among the elderly are diet related and nutrition dependent. There is an urgent need to prevent physiological aging getting converted in to pathological aging by creating health and nutrition awareness among elderly.

Effects of nine social life indicators on age-adjusted and age-specific annual suicide mortality of male and female Japanese population in the years 1953-96 were investigated by multiple regression analysis on time series data. Unemployment rate was significantly related to the age-adjusted mortality in both males and females. Also, female labour force participation was positively related to the male mortality; persons and 65 and above was inversely related to the male mortality. Results on the age-specific mortality indicated that: during the 44 yr, (1) unemployment significantly related with the mortality of young, middle-aged and elderly males and young females; (2) female labour force participation significantly related with the mortality of young and elderly males and young females; aged population significantly related with the mortality of middle-aged and elderly males; (4) young population significantly related with the mortality of young and middle-aged males and females; (5) divorce significantly related with the mortality of middle-aged and elderly males and young males and females; (6) persons employed in primary industries significantly related with the mortality in middle-aged males and young males and females; and (7) population density significantly related with the mortality of middle-aged males and young females.

Middle-aged females are resistant to LPS-induced learning deficits: Sex comparison

The study reported in this article attempted to obtain normative acoustic data of voice for elderly male and female speakers and to explore the educational implications of the effects of aging on those selected acoustic parameters. Voice samples from 21 male and 23 female elderly speakers aged 70 to 80 years were obtained on measures of 15 selected Multi-Dimensional Voice Program acoustic parameters. These data then were compared with the published norms for young and middle-aged adults. The results showed that, compared with young and middle-aged adults, elderly speakers had significantly different (usually poorer) vocal output on all of the selected acoustic parameters of voice. These findings illustrate the importance of establishing acoustic norms and thresholds for elderly men and women and stress the necessity of using discretion in making dragnostic measurements of elderly speakers' acoustic parameters of voice. This article also highlights the educational implications of such aging voice changes.

This phase 1, open-label, single-dose, parallel-group study evaluated the pharmacokinetics (PK) of isavuconazole after a single oral dose of the prodrug isavuconazonium sulfate in healthy nonelderly (age, 18 to 45 years) and elderly (age, ≥65 years) males and females. Overall, 48 subjects were enrolled in the study (n = 12 each in groups of nonelderly males and females and elderly males and females). All subjects received a single oral dose of 372 mg of isavuconazonium sulfate (equivalent to 200 mg isavuconazole). PK samples were collected for analysis of isavuconazole plasma concentrations from the predose time point up to 336 h postdose. Data were analyzed using population pharmacokinetic (PPK) analysis. The resulting PPK model included two compartments with Weibull absorption function as well as interindividual variability with respect to clearance, intercompartment clearance, volumes of central and peripheral compartments, and two Weibull absorption parameters, RA and KAMAX. The PPK analysis showed that elderly females had the highest exposure versus males (ratio of total area under the time-concentration curve [AUC], 138; 90% confidence interval [CI], 118 to 161) and versus nonelderly females (ratio of AUC, 147; 90% CI, 123 to 176). Higher exposures in elderly females were not associated with significant toxicity or treatment-emergent adverse events, as measured in this study. No dose adjustments appear to be necessary based on either age group or sex even with an increase in exposure for elderly females. (This study has been registered at ClinicalTrials.gov under registration no. NCT01657890.).

Savory crispy or fried snack (SCFS), sugary snack(SS), and sugar-sweetened beverage (SSB) consumption are associated with a higher prevalence of obesity and non-communicable diseases. So, we estimated the consumption of SCFS, SS, and SSB among elderly males and females in Bangladesh. We also reported the factors associated with their consumption using data from a nationwide cross-sectional study. We interviewed 2,482 (51.52%) elderly males and 2,335 (48.47%) elderly females for the recall for the past seven days on the intake of SCFS, SS, and SSB from 82 randomly selected clusters from rural, non-slum urban, and slum areas in Bangladesh. Sociodemographic and anthropometry data were also collected. Consumption of SCFS, SS, and SSB for ≥1 time per week was reported by 884 (31.5%), 1,696 (66.1%), and 1,911 (69.3%) of the elderly males and 516 (20.1%), 1,367 (53.9%), and 1,171 (34.1%) of the elderly females, respectively. Both elderly males and females from slum and non-slum urban areas consumed more SSB than their rural counterparts. Higher level of television viewing was associated with increased frequency of intake of SCFS, SS, and SSB among elderly males and SSB intake among elderly females. Nutritional status was not associated with the consumption of these foods and drinks among the elderly; however, overweight males consumed SSB less frequently. In Bangladesh, elderly males and females frequently consume unhealthy snacks and drinks. Considering their detrimental effect on health, it is necessary to reduce their consumption through policy and program measures and promote healthier foods and beverages.

The occurrence of hypertension, leading to various life-threatening complications in the elderly is a widely recognized problem. The changes of body composition were determined in 120 control and untreated hypertensive subjects of various ages. In middle-aged hypertensive males, the total blood volume and plasma volume increased significantly compared to those of the healthy controls, while this increase was not significant in the case of hypertensive middle-aged females. In contrast, in the elderly hypertensive male subjects, the volume of all fluid components decreased, except the total body fat and the vascular volumes. There was a slight, statistically non-significant, increase in all the vascular volumes except in the red cell mass. The elderly hypertensive females showed the same tendency compared to the healthy controls of the same age. The vascular compartments seem to be decreased in elderly males, compared to those of the middle-aged males, while slightly increased in elderly females.

This study sought to provide preliminary normative data for the vocal productions of 44 Euro-American and 40 African-American elderly speakers and to test the hypotheses that (1) Euro-American elderly speakers do not have significantly different acoustic parameters of voice from African-American elderly speakers, and (2) elderly male speakers (both Euro-American and African-American) do not have significantly different acoustic parameters of voice from elderly female speakers (both Euro-American and African-American). Voice samples from groups of 44 Euro-American (21 men and 23 women) and 40 African-American (20 men and 20 women) elderly speakers (ages 70 to 80 years) from northeastern Arkansas were compared on measures of 15 selected multidimensional voice profile (KAY Elemetrics) acoustic parameters. Analysis show that Euro-American elderly speakers did not differ significantly from African-American elderly speakers on the measurements of all the selected acoustic parameters of voice, and elderly male speakers as a group differed from elderly female speakers on the measurements of absolute jitter, soft phonation index, and standard deviation of the fundamental frequency as well as fundamental frequency in Hz. The findings suggest it may not be necessary to establish separate acoustic norms of voice for Euro-American and African-American elderly speakers. However, some acoustic parameters of voice are highly sex-dependent, and different norms may be needed for male and female speakers regardless of their racial origins.

This study sought to provide preliminary normative data for the vocal productions of 44 Euro-American and 40 African-American elderly speakers and to test the hypotheses that (1) Euro-American elderly speakers do not have significantly different acoustic parameters of voice from African-American elderly speakers, and (2) elderly male speakers (both Euro-American and African-American) do not have significantly different acoustic parameters of voice from elderly female speakers (both Euro-American and African-American). Voice samples from groups of 44 Euro-American (21 men and 23 women) and 40 African-American (20 men and 20 women) elderly speakers (ages 70 to 80 years) from northeastern Arkansas were compared on measures of 15 selected multidimensional voice profile (KAY Elemetrics) acoustic parameters. Analysis show that Euro-American elderly speakers did not differ significantly from African-American elderly speakers on the measurements of all the selected acoustic parameters of voice, and elderly male speakers as a group differed from elderly female speakers on the measurements of absolute jitter, soft phonation index, and standard deviation of the fundamental frequency as well as fundamental frequency in Hz. The findings suggest it may not be necessary to establish separate acoustic norms of voice for Euro-American and African-American elderly speakers. However, some acoustic parameters of voice are highly sex-dependent, and different norms may be needed for male and female speakers regardless of their racial origins.

Effect of age and gender in non-smokers with oral squamous cell carcinoma: Multi-institutional study

Effects of a 12-week progressive strength training period on serum concentrations of testosterone, cortisol and sex-hormone-binding globulin (SHBG) as well as on strength development of the leg extensor muscles were investigated in nine middle-aged males (M50; range 44-57 years) and in nine middle-aged females (F50; range 43-54 years) as well as in 10 elderly males (M70; range 64-73 years) and in 11 elderly females (F70; range 66-73 years). Substantial increases took place in maximal isometric strength during the 12-week training period both in M50 (from 2834 +/- 452 to 3941 +/- 772 N; P < 0.001) and in F50 (from 2627 +/- 725 to 3488 +/- 1017 N; P < 0.001) as well as in M70 (from 2591 +/- 736 to 3075 +/- 845 N; P < 0.01) and in F70 (from 1816 +/- 427 to 2483 +/- 408 N; P < 0.001). The relative increases in strength during the 12-week training period did not differ significantly between the groups. However, during the last 4 weeks of the training none of the groups demonstrated further increases in strength but it actually decreased in F50 (P < 0.05), M70 (P < 0.01) and in F70 (P < 0.05). No systematic changes were observed during the training in the mean concentrations of serum total testosterone, free testosterone, cortisol, and SHBG, nor in testosterone/cortisol and testosterone/SHBG ratios. However, the individual levels of serum testosterone and testosterone/cortisol ratio and the individual changes in strength during the last four most intensive training weeks of the 12-week period were in significant positive linear correlation in F70 (r = 0.57; P < 0.05) and in M70 (r = 0.61; P < 0.05).(ABSTRACT TRUNCATED AT 250 WORDS)

ObjectiveTo evaluate the genetic effects of sex hormone traits on the development of mental traits in middle-aged adults.MethodsThe SNPs associated with sex hormone traits were derived from a two-stage genome-wide association study (GWAS). Four sex hormone traits were selected in the current study, including sex hormone-binding globulin (SHBG), testosterone, bioavailable testosterone and estradiol. The polygenic risk score (PRS) of sex hormone traits were calculated from individual-level genotype data of the United Kingdom (UK) Biobank cohort. We then used logistic and linear regression models to assess the associations between individual PRS of sex hormone traits and the frequency of alcohol consumption, anxiety, intelligence and so on. Finally, gene-environment-wide interaction study (GEWIS) was performed to detect novel candidate genes interacting with the sex hormone traits on the development of fluid intelligence and the frequency of smoking and alcohol consumption by PLINK2.0.ResultsWe observed positive association between SHBG and the frequency of alcohol consumption (b = 0.0101, p = 3.84 × 10–11) in middle-aged males and females. In addition, estradiol was positively associated with the frequency of alcohol consumption (b = 0.0128, p = 1.96 × 10–8) in middle-aged males. Moreover, bioavailable testosterone was associated with the fluid intelligence (b = − 0.0136, p = 5.74 × 10–5) in middle-aged females. Finally, GEWIS identified one significant loci, Tenascin R (TNR) (rs34633780, p = 3.45 × 10–8) interacting with total testosterone for fluid intelligence.ConclusionOur study results support the genetic effects of sex hormone traits on the development of intelligence and the frequency of alcohol consumption in middle-aged adults in UK.

Background and aim: During the past few decades, the aging population has increased. With aging, there is an increase in functional limitations. The aim of this study was to analyze sociodemographic factors associated with physical functioning impairment in elderly males and females. Methods: This population-based modeling study based on a data from a third national study of health of Serbian inhabitants from 2013 in Serbia included 3540 elderly participants 65 years of age and above from Serbia. Physical functioning for both genders was categorized as follows: PF1-walking half a kilometer on level ground without the assistance of any mobility aids and PF2-walking up or down 12 steps. Modeling of physical functioning for both genders was categorized as follows: Model 1: inability to perform PF1, Model 2: some/a lot of difficulty in performing PF1, Model 3: inability to perform PF2, and Model 4: some/a lot of difficulty in performing PF2. Further variables were evaluated: age, education level, marital status, body mass index (BMI), wealth index, and place of residence. Logistic regression was performed to identify the variables that are factors associated with PF1 and PF2 in elderly males and females. Results: Statistically significant factors were as follows: age (Model 1 (male OR: 2.591; female OR: 4.708); Model 2 (male OR: 1.791; female OR: 2.354); Model 3 (male OR: 2.386; female OR: 4.985); Model 4 (male OR: 1.883; female OR: 2.772)); BMI (Model 2 (female OR: 1.348); Model 4 (female OR: 1.329)), marital status (Model 2 (female OR: 0.713); Model 4 (male OR: 0.688)); education level (Model 1 (male OR: 0.626; female OR: 0.537); Model 2 (male OR: 0.811; female OR: 0.653); Model 3 (male OR: 0.697; female OR: 0.494); Model 4 (male OR: 0.784; female OR: 0.639)); wealth index (Model 2 (male OR: 0.823; female OR: 0.740); Model 3 (male OR: 0.724); Model 4 (male OR: 0.787; female OR: 0.731)); and place of residence (Model 1 (female OR: 1.704); Model 3 (female OR: 1.575)). Conclusions: Increased age, being single, a lower education level, and a lower wealth index were factors associated with functional disability in the elderly of both genders, while an increased BMI and living in another place than a city were factors associated with functional disability in elderly females. Specific social strategies bearing in mind possible gender differences should be created and implemented in order to optimize the physical functioning, mobility, and participation of the elderly.