Abstract
Although dietary fiber treatment alters the gut microbiota and its metabolite production, it is unclear whether or not exercise habits can have a supplemental effect on changes in gut microbiota in dietary fiber-treated mice. To clarify the supplemental effect of voluntary exercise on gut microbiota in partially hydrolyzed guar gum (PHGG), which is a soluble dietary fiber, treated mice under high-fat diet (HFD) feeding, 4-week-old male C57BL/6J mice (n = 80) were randomly divided into two dietary groups: the control-diet (CD) and HFD. Then, each dietary group was treated with or without PHGG, and with or without wheel running. After the experimental period, measurement of maximal oxygen consumption, a glucose tolerance test and fecal materials collection for analysis of gut microbiota were carried out. Voluntary exercise load in PHGG treatment under HFD feeding showed the supplemental effect of exercise on obesity (p < 0.01) and glucose tolerance (p < 0.01). Additionally, in both CD and HFD groups, voluntary exercise accelerated the decrease in the Firmicutes/Bacteroidetes ratio in mice fed with PHGG (p < 0.01). These findings suggest that voluntary exercise might activate the prevention of obesity and insulin resistance more via change in gut microbiota in mice administrated with PHGG.
Highlights
The ingestion of dietary fiber is a potential prebiotic, and may lead to numerous health benefits on the host [1,2]
We expected that partially hydrolyzed guar gum (PHGG) intake might be supplemented by voluntary exercise because this study, we expected that
PHGG,Inwhich is noviscous in form, is losing functionary control [3]
Summary
The ingestion of dietary fiber is a potential prebiotic, and may lead to numerous health benefits on the host [1,2]. The main object of prebiotics is to stimulate the growth and activity of beneficial bacteria in the gastrointestinal tract (GT) [1,2]. Guar gum is one of these dietary fibers, and is classified in soluble and fermentable fibers. In an attempt to make guar gum more palatable, hydrolyzed guar gum (partially hydrolyzed guar gum (PHGG)) was produced resulting in a low viscosity/nonviscous. PHGG is classified as low viscous in fibers, but it is well fermented [1]. The beneficial effect, such as improved glycemic control, is abolished when the guar gum is hydrolyzed to a nonviscous
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