Abstract
Mercuric chloride may deposit in the liver with a high metabolic rate, delivering substrate and energy from one metabolic system to others, and processing and synthesizing various substances transported to the body. This research aimed to determine the effect of vitamin E administration on liver histopathology of mice (Mus musculus) exposed to mercuric chloride and to determine the histopathological image of the liver. Samples were grouped into P0 (not treated), P1 (mercuric chloride 50 mg/kgBW), P2 (mercuric chloride 50mg/kgBW + vitamin E 50mg/kgBW), P3 (mercuric chloride 50mg/kgBW + vitamin E 100mg/kgBW), and P4 (mercuric chloride 50mg/kgBW + vitamin E 150mg/kgBW) using experiment laboratory method. The data were analyzed using the One Way ANOVA to recognize the difference in changes in vitamin E on hepatocytes damage exposed to mercury chloride. The results showed mercury chloride damages hepatocyte, while the administration of vitamin E as a whole showed changes in hepatocyte repair. The optimal dose for hepatocyte repair is 100mg/kgBW.Â
Highlights
One of the heavy metals that is often found is mercury, especially mercuric chloride
This research was conducted using experimental laboratory with a post-test only control group design to determine the effect of vitamin E administration on the liver of mice exposed to mercury
Before the damaged hepatocytes undergo reversible changes called parenchymous degeneration and hydropic degeneration, parenchymal degeneration is characterized by cell swelling, cytoplasmic opacification, and granules appearing in the cytoplasm
Summary
One of the heavy metals that is often found is mercury, especially mercuric chloride. Mercury penetrates the body tissues through several ways, such as respiratory tract, digestive system, and skin. The metal enters through the digestive system by passing through the respiratory tract so that it is carried by the blood and is circulated throughout the body. The danger caused by the mercury compound is the emergence of organ damages, especially the liver (1). Liver is an organ located in the right upper quadrant of the abdomen under the diaphragm and protected by ribs. The liver functions as the body's metabolic center, digestion aids, and toxic-substances protection through the detoxification process. Most of the chemicals or drugs that enter through the digestive system will pass through the liver as the central metabolic organ. The liver will suffer damage if the exposure continues (2)
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