Abstract
PURPOSE The goal of this study was to demonstrate whether treadmill exercise have an effect on the level of α-synuclein and microRNA (miRNA) in striatum of Parkinsonâs Disease (PD) induced mouse models. METHODS To induced mouse model of PD, administered to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP, 25 mg/kg) and Probenecid (250 mg/kg) by intraperitoneal injections, 2 times per week during 5 weeks. The groups were randomly divided into 3 groups: CON (C57BL/6 control, n=7), MPTP-C (MPTP control, n=7), and ME (MPTP+Exercise, n=7) and treadmill exercise was performed for 8 weeks (10 m/min, 60 min/day, 5 days/week). RESULTS The result show that treadmill exercise significantly improved locomotor function in ME group compared with MPTP-C group in rotarod performance test. Moreover, treadmill exercise was significantly increased levels of miR-153 as regulating SNCA mRNA in ME group compared with MPTP-C group. Conversely, treadmill exercise was significantly decreased levels of SNCA mRNA and α-synuclein in ME group compared with MPTP-C group. We also found that treadmill exercise was significantly increased levels of tyrosine hydroxylase in ME group compared with MPTP-C group. CONCLUSIONS Taken together, these results indicated that treadmill exercise could ameliorate pathologic features of PD via regulating miRNA against MPTP induced mouse model of PD. ìì¸ì´: íí¨ì¨ì§í, 1-ë©í¸-4íë-1,2,3,6-í í¸ë¼íëë¡í¼ë¦¬ë, ìíìëí´ë¦°, í°ë¡ì ìì°íí¨ì, í¸ë ëë°ì´ë Keywords: Parkinsonâs disease, MPTP, α-synuclein, Tyrosine hydroxylase, Treadmill exercise
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.