Abstract
To evaluate the effects of a single dose of trazodone on the standardized field sobriety test (SFST). A randomized, double-blinded, repeated-measures study. Forty-five healthy adult subjects. University campus. The SFST consists of the horizontal gaze nystagmus, walk-and-turn, and one-leg stand tests. Subjects were administered a baseline SFST and at 2 hours after the administration of either trazodone 100mg (30 subjects) or acetaminophen 650mg (15 subjects). At 2 hours post drug administration, there were no statistical differences in failure rates between the trazodone and acetaminophen groups (53.3% vs 20.0%, p=0.054). However, the trazodone group exhibited more impairment clues within the individual tests of the SFST than the acetaminophen group. A one-time dose of trazodone 100mg does not result in an increased SFST failure rate at 2 hours postdosing compared to acetaminophen 650mg. However, the number of individual impairment clues detected is increased with trazodone. Trazodone 100mg may cause cognitive driving impairment.
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