Abstract
Studies were made to determine if hyaluronidase, when incorporated into ointments, affected the penetration of medication contained in ointments applied to the skin. Four substances were tested: sulfanilamide, sodium sulfanilamide, sodium iodide, and sodium chloride. Three different ointment bases were used: an oleaginous base, an absorption base, and a washable emulsion type base. The ointments were applied to the intact skin of guinea pigs, and a technique using radioactive isotopes is reported for determining the extent of penetration of the labeled medicaments. It was found that the substances studied showed a limited degree of penetration into the skin from the bases used, but except in the case of sodium iodide the penetration was not appreciably affected by hyaluronidase.
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