Abstract
The effect of severity of liver cirrhosis, an alcoholic and non-alcoholic genesis, on the results of serum lipids and lipoproteins was evaluated. Serum cholesterol, triglycerides, high-density lipoprotein cholesterol (HDL-Ch), and low-density lipoprotein cholesterol (LDL-Ch) were measured in the sera of 59 patients suffering from alcoholic cirrhosis and 34 patients with non-alcoholic cirrhosis. The level of serum triglycerides depends on the severity of liver damage in alcoholic liver cirrhosis, being the highest in Child-Pugh score B. The severity of liver damage significantly affects the HDL-Ch and LDL-Ch levels in cirrhosis of non-alcoholic origin, reaching the highest value for LDL-Ch and the lowest for HDL-Ch in score C. It should not be generalized that the levels of lipids and lipoproteins in liver cirrhosis progressively diminished with the deterioration of liver function. The serum HDL-Ch and LDL-Ch may be considered as markers of severity of liver damage in non-alcoholic cirrhosis, but the triglycerides only in disease of alcoholic origin.
Highlights
The liver plays a crucial role in the synthesis, secretion, catabolism, and storage of lipids and lipoproteins
Studies were carried out on 59 patients suffering from alcoholic cirrhosis (ALC) (14 females and 45 males) and 34 patients with nonalcoholic cirrhosis (NALC) (16 females and 18 males) who were admitted in the Department of Infectious Diseases and Hepatology
Only the level of serum triglycerides appears to be dependent on the severity of liver damage evaluated by Child-Pugh score (H = 6.676, P = 0.036) (Fig. 1)
Summary
The liver plays a crucial role in the synthesis, secretion, catabolism, and storage of lipids and lipoproteins. It has been known that the major effects of high alcohol consumption on lipids metabolism are the excessive synthesis of triglycerides, hypertriglyceridemia and hypercholesterolemia, defective esterification of plasma cholesterol, and decreased level of high-density lipoprotein cholesterol [7]. These changes should be contrasted with the effects produced by moderate alcohol consumption which can be reversible with cessation of alcohol drinking [8]. The aim of this study was to evaluate the influence of liver cirrhosis severity, an alcoholic and nonalcoholic origin, on the concentration of serum lipids and lipoproteins
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