Abstract
The purified anticoagulant principle of Agkistrodon acutus venom had marked anticoagulant action when tested on whole blood clotting time, calcium clotting time and plasma prothrombin time. It did not destroy fibrinogen, induce fibrinolysis, inactivate thrombin nor interfere with the interaction between thrombin and fibrinogen. However a marked inhibition of prothrombin activation was not due to the destruction of prothrombin or its activation factors, but due to an interference in the interaction between prothrombin and its activation factors because of the reversible binding of these factors with the anticoagulant principle of the venom.
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