The Effect of The Mitomycin C on Anophthalmic Contracted Socket (Literature Review)

Abstract

This study aims to provide information about the effect of the Mitomycin C on contracted sockets surgery so that Mitomycin C can inhibit migration of fibroblast and synthesis of collagen thus causing reduce fibrosis in vitro and in vivo and a significant reduction of scarring. The literature study used is the literature of the last 10 years in 2021. Literature searches were used from the Science Direct, PubMed, and Google Scholar electronic databases. The initial stage obtained 43 national and international articles that are considered relevant. The search for articles using the keywords “anophthalmic socket and mitomycin c”, and “contracted socket and mitomycin c” then continued at the screening stage, which in the end obtained 5 articles that matched the object to be discussed.. The results of this study explain that the Mitomycin C has an effect in a decrease fibroblast in contracted socket surgery and has been successful in reducing recurrence by inhibiting fibrosis.