Abstract
Purpose: We studied early and delayed contrast-enhanced CT to determine the effects of the degree of luminal enhancement on the measurement of plaque size compared to T1-weighted MRI. Materials and Methods: T1-weighted MRI and a two-phase contrast-enhanced CT was performed in 5 New Zealand white rabbits with atherosclerosis. Early-phase images were acquired during an expected peak enhancement period of the lumen; delayedphase images were acquired 240 sec after administration of the contrast media. Anteroposterior and lateral luminal diameters (APD, LD), luminal area (LA), total vessel area (TVA), and plaque area (PA) of the aorta were measured on MRI and CT, respectively and compared to each other. Results: A total of 78 slices of the aorta were analyzed. PA, measured on T1-weighted MR images, was significantly greater than PA for both early-phase and delayed-phase CT (p (p (p (p = 0.159) for MRI vs. early-phase CT, MRI vs. delayed-phase CT, and early-phase CT vs. delayed-phase CT, respectively. Conclusion: Different luminal densities by contrast enhancement do not affect the CT measurement of plaque area for the detection of obstructive coronary artery disease.
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