The Effect of spirulina on Apoptosis (Stored Biology Materials) To Pregnant Rat Wistar in the Second Trimester Wich is Induced By IL-6

Abstract

The pathology of pregnancy is very diverse, one of which is preeclampsia. Preeclampsia is a complication of pregnancy characterized by hypertension with proteinuria and oedema after 20 weeks gestation. The prevalence of preeclampsia in hospitals across Indonesia varies considerably, that is between 5.75%-9.17% and increased by 40% over the last few years worldwide. Several studies had shown that Spirulina has a microscopic filamentous cyanobacterium contains C-phycocyanin which is a substance with potent cancer chemopreventive activity. The purpose of this study was to determine whether there is the influence of Spirulina on the apoptosis of trophoblast cells expression exposed by IL-6 on pregnant Wistar rats at two trimesters. The type of this result used Post Test Only Control Group Design. This study used a sample group of experimental animals white rat comprising an experimental group (treated) and control groups. The independent variables in this study were Spirulina dose, while the dependent variable was the apoptosis of Wistar rat trophoblast cells expression that is pregnant with preeclampsia model. The results of this study showed that Spirulina can decrease Apoptosis sensitiotrofoblast cells expression in rats models of preeclampsia. The highest apoptotic expression average was in the P0 group, the group was given IL-6 (iv) dose of 5 mg/day was 62.380 and the lowest average of apoptotic expression was in the P3 group, the group was given IL-6 ( iv) and Spirulina with a dose of 40 mg/day (oral) is 44.260.