Abstract
The data obtained by mathematical modeling of the occurrence of open states between nitrogenous bases in a D. melanogaster gene where a protium atom is replaced by deuterium are presented. It was shown that in the physiological range of deuterium concentrations substitution of deuterium for protium increases the probability of hydrogen-bond disruption between complementary bases by 0.22–0.60%. This result suggests that deuterium can decelerate the transcriptional reading of genetic information. At the same time, under conditions that weaken the hydrogen bonds between the strands of a DNA molecule, replacement of protium with deuterium facilitates the formation of open states, increasing the probability of base modification induced by damaging environmental factors.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.