Abstract
Seizure severity is an important aspect of epilepsy. The relationship between seizure severity and quality of life in epilepsy, however, has been incompletely explored. With a data set of 118 women from the baseline phase of a clinical treatment trial, the relationship between seizure severity and aspects of quality of life was evaluated. Two domains of the Quality of Life in Epilepsy-31 (QOLIE-31) correlated highly significantly with seizure severity: Seizure Worry ( r = −0.265, P = .004) and Social Functioning ( r = −0.280, P = 0.002). Two additional domains were significantly correlated: Overall Quality of Life ( r = −0.210, P = 0.023) and Cognitive ( r = −0.209, P = 0.024). When the potentially confounding effect of depression, measured by the Beck Depression Inventory, was controlled for, the regression of seizure severity with QOLIE-31 Seizure Worry remained significant ( P = 0.006, R 2 = 0.153), as did the regression with QOLIE-31 Social Functioning ( P = 0.002, R 2 = 0.184) and the regression with QOLIE-31 Cognitive ( P = 0.037, R 2 = 0.30). These findings indicate that severe and potentially injurious seizure behaviors contribute to anxiety and socially avoidant behavior for persons with intractable epilepsy.
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