Abstract
1. 1. Lateral ciliary activity was studied in whole ctenidial preparations in the oyster, Crassostrea virginica. 2. 2. It has been previously demonstrated by the author that the lateral cilia are under the control of axons present in the branchial nerve and that serotonin (5-HT) is the released neurocilioexcitatory neurotransmitter. 3. 3. This study confirms the above findings and in addition demonstrates that perfusates containing salyrgan (calcium-ATPase poison) in the presence of external calcium, in the various test salinities, is cilioinhibitory. The latter effect was reduced in the presence of the calcium chelator, EGTA. 4. 4. The addition of lanthanum to the salyrgan perfusate enhances the cilioinhibitory response of the latter, presumably by binding in an irreversible manner to calcium channels within the lateral ciliated cell membrane. This functions to more effectively stop the calcium-pump. 5. 5. It is postulated that salyrgan brings about an increase in the intracellular calcium pool within the lateral ciliated cell by poisoning the calcium-pump. This is further exacerbated in the presence of lanthanum and in the absence of the neurocilioexcitatory transmitter in the cut branchial nerve preparations. The latter presumably functions as a calcium-pump activator.
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