Abstract
Background: The favorable influences of saffron supplementation on metabolic diseases have previously been shown. We aimed to assess the effects of saffron supplementation on blood pressure in adults. Methods: A systematic search was performed in Scopus, Embase, and the Cochrane library databases to find randomized controlled trials (RCTs) related to the effect of saffron supplementation on blood pressure in adults up to March 2021. The primary search yielded 182 publications, of which eight RCTs were eligible. Results: Our results showed that saffron supplementation resulted in a significant decrease in systolic blood pressure (weighted mean difference (WMD): −0.65 mmHg; 95% CI: −1.12 to −0.18, p = 0.006) and diastolic blood pressure (DBP) (WMD: −1.23 mmHg; 95% CI: −1.64 to −0.81, p < 0.001). Moreover, saffron supplementation reduced DBP in a non-linear fashion, based on duration (r = −2.45, p-nonlinearity = 0.008). Conclusions: Saffron supplementation may significantly improve both systolic and diastolic blood pressure in adults. It should be noted that the hypotensive effects of saffron supplementation were small and may not reach clinical importance.
Highlights
High blood pressure, known as hypertension (HTN), is one of the most severe and prevalent global diseases, estimated to be implicated in 9.4 million global deaths annually [1]
Despite some reports in the literature indicating the positive influence of saffron supplementation on blood pressure (BP), there was a distinct lack of an overarching consensus
We found that saffron supplementation was associated with a decrease in systolic blood pressure (SBP) and diastolic blood pressure (DBP) when compared to a control group
Summary
Known as hypertension (HTN), is one of the most severe and prevalent global diseases, estimated to be implicated in 9.4 million global deaths annually [1]. The outcomes of empirical studies have indicated a positive correlation between high blood pressure (BP) and the incidence of chronic diseases, such as cardiovascular diseases [2], myocardial infarction [3], and kidney dysfunction [4,5]. To mediate such issues, controlling BP is essential. Methods: A systematic search was performed in Scopus, Embase, and the Cochrane library databases to find randomized controlled trials (RCTs) related to the effect of saffron supplementation on blood pressure in adults up to March 2021. It should be noted that the hypotensive effects of saffron supplementation were small and may not reach clinical importance
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