The effect of remote ischemic preconditioning on clinical outcomes in patients with lung injury: a Meta-analysis of the randomized controlled trials

Abstract

Objective To systematically evaluate the effect of remote ischemic preconditioning(RIPC) on lung injury induced by many kinds of fators. Methods The literatures were selected according to the inclusive and exclusive criteria from the following databases including PubMed, Embase, Medline, CNKI, VIP Journal Network Publishing Database, Chinese Biomedical Literature Database, Chinese Medical Citation Index. The primary evaluation indicators (postoperative ICU stay time and mechanical ventilation time) and the secondary indicators[serum IL-6, TNF-α, IL-8 levels at 24 h, alveolar-arterial oxygen tension gradient(A-aDO2), PaO2/FiO2, respiratory index(RI) at 24 h after operation] were analyzed. Software RevMan 5.3 and STATA 12.0 were utilized to perform Meta analysis. Results Our search yielded 8 studies including 476 patients. 237 patients of all were allocated into the RIPC group, the others into the control group. Compared with the control group, the ICU stay time and mechanical ventilation time were reduced in RIPC group(P<0.05), and TNF-α level at 24 h after operation was lower in RIPC group (P<0.05). Furtherly, the standard mean difference(SMD) and 95%CI of them were respectively-0.03(-0.41,-0.05),-0.2(-0.39,-0.01),-0.85(-1.35, 0.34). Conclusions Remote ischemic preconditioning could decrease ICU stay time and mechanical ventilation time, improving the clinical outcomes of patients with lung injury. Key words: Remote ischemic preconditioning; Lung injury; Meta-analysis