Abstract
The effect of prostaglandin F2α (PGF2α) on peripheral plasma and ovarian progesterone concentrations has been studied in pregnant hamsters. PGF2α administered subcutaneously at a dose of 0.1 mg/day on days 5 through 7 post-coitus lowered both plasma and ovarian progesterone levels and terminated pregnancy in all animals. Ovaries from PGF2α-treated hamsters showed histological evidence of luteal disorganization on days 6 and 7 post-coitus. A 10-fold increase in the dose of PGF2α (1 mg/day) caused an indication of luteal breakdown within 5 hr of the initial treatment. Ovarian weights, plasma progesterone levels, and luteal morphology of females after treatment and pregnancy termination were similar to those of untreated cycling females. Exogenous progesterone maintained pregnancy in PGF2α-treated females.
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Schedule a callMore From: Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.)
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