There is growing interest in supplementation with pro-/synbiotics for brain and mental health. Animal studies have reported that pro-/synbiotic administration can increase the brain-derived neurotrophic factor (BDNF), a key regulator of neuronal function. Nevertheless, the results obtained from human studies are inconsistent and conflicting. Therefore, we aimed to conduct a systematic review and meta-analysis of randomized controlled trials (RCTs) to investigate the impact of pro-/synbiotic supplementation on BDNF levels. Scopus, Medline, Web of Science, Cochrane Library, and Google Scholar were searched up to July 10, 2022 to find eligible RCTs. The weighted mean difference (WMD) and 95% confidence interval (CI) were computed for BDNF using a random-effects model. In the present study, 10 RCTs with 12 treatment arms consisting of 652 participants were included. The meta-analysis revealed that supplementation with pro-/synbiotics significantly increased BDNF concentrations in comparison with the placebo (WMD: 0.20 ng mL-1, 95% CI: 0.06 to 0.34, I2 = 86.6%). Moreover, subgroup analysis showed that the target population, ethnicity and the mean age of participants, the number and type of probiotic strains, administration form, and the dose and duration of pro-/synbiotic supplementation were the potential sources of heterogeneity between RCTs. In conclusion, pro-/synbiotic administration can be considered as a BDNF enhancer and a possible brain booster.
Brain-derived Neurotrophic Factor Synbiotic Supplementation Synbiotic Administration Weighted Mean Difference Randomized Controlled Trials Potential Sources Of Heterogeneity Brain-derived Neurotrophic Factor Levels Mean Age Of Participants Ng mL-1 Confidence Interval
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Round-ups are the summaries of handpicked papers around trending topics published every week. These would enable you to scan through a collection of papers and decide if the paper is relevant to you before actually investing time into reading it.
Climate change Research Articles published between Sep 12, 2022 to Sep 18, 2022
Sep 19, 2022
Articles Included: 5
Rainfall projections from the Coupled Model Intercomparison Project (CMIP) models are strongly tied to projected sea surface temperature (SST) spatial...Read More
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