Abstract
The effect of 2-hydroxypropyl-β-cyclodextrin (HPβCD), polyvinylpyrrolidone (PVP) and hydroxypropyl methylcellulose (HPMC) on the flux of hydrocortisone from an aqueous solution through hairless mouse skin was investigated in vitro. When the drug concentration was kept constant and the HPβCD concentration was gradually increased, the flux through the skin was increased until all the drug had dissolved; after that the flux decreased with increasing HPβCD concentration. PVP and HPMC increased the hydrocortisone-HPβCD complexation resulting in increased solubilization of the drug. Also, the transdermal delivery of hydrocortisone could be increased by addition of a small amount of PVP or HPMC to an HPβCD-containing vehicle.
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